Are there any fundamental differences between prokaryotes and eukaryotes?

A cell that has a formed nucleus in its structure – chromosomes, nucleoli, nuclear juice, nuclear envelope and all the main organelles – is eukaryotic. In the absence of a malformed nucleus in the cell, there are only chromosomes, and most organelles (except for ribosomes) – prokarite. Mature erythrocytes, do not have a formed nucleus, are still eukaryotes. In the initial stages of formation, these cells have a formed nucleus, but then it is destroyed.
It follows from everything that prokaryotes and eukaryotes are fundamentally different from each other.

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