A man with optic nerve atrophy (a trait linked to the X chromosome) married a woman with normal vision

A man with optic nerve atrophy (a trait linked to the X chromosome) married a woman with normal vision, whose father suffered from this disease. To determine the genotypes of men and women, phenotypes and genotypes of possible offspring. What is the probability of having daughters with optic nerve atrophy.

Since the woman has normal vision, despite the fact that she received from her father an X chromosome containing the gene responsible for atrophy, this gene is recessive (for example, f). Female genotype XFXf. The man, like the woman’s father, has the XfY genotype. Children’s options: XFXf (healthy girl, carrier of the atrophy gene), XFY (healthy boy), XfXf (sick girl), XfY (sick boy). The probability of having a girl with atrophy is 50% if we consider only girls, and 25% if we consider all offspring, including boys.



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