Does the chemical nature of an element change when alpha particles are emitted by its nuclei?

Part of the answer to the question is contained in the modern formulation of the periodic law of D.I.Mendeleev. According to this law, the properties of chemical elements depend on the charge of the atomic nucleus of chemical elements. This dependence is periodic – the properties are repeated with an increase in the charge by a certain number of units. The physical essence of the law is that the configuration of the outer electron shell plays an essential role for the ability of an atom to enter into chemical reactions, and its structure is periodically repeated with increasing charge.
In the case of a nucleus that has emitted an alpha particle, we get a nucleus that has lost two protons and two neutrons, that is, its charge has decreased by two units. Since the atom is neutral, its outer electron shell will also lose two electrons and this will affect its chemical properties. In fact, after the alpha decay of the nucleus, it will already be the nucleus of an atom of another chemical element. For example, after the alpha decay of the plutonium 239 nucleus, the uranium 235 nucleus is formed.

Answer: Changes.