How has the position of the Italian states changed after the Italian wars?

The Italian wars have affected Italy itself in the worst possible way. Italy was not an equal participant in the war between France and Spain. This territory remained only a battleground, especially the Kingdom of Naples.
After a series of debilitating conflicts in Italy, the Spanish imperial court took hold, and the fragmentation of the already weakened and remote city-states and provinces increased. Italy for a long time remained outside international relations in Europe and the world.