The state that hindered the development of trade between Europeans and the East in the Mediterranean?

We are talking about the period from the second half of the 15th century, the Ottoman Empire became such a state. in 1453 the Turks took Constantinople and took control of the trade routes through the straits between the Black and Aegean Seas. They later took possession of Cyprus, Greece, Rhodes, the southern coast of Crimea (1475), Trabzon, Albania and the Middle East by 1520.

As a result, the Europeans began to look for a sea route to India and in 1498 the Portuguese sailed there.