What are the main difficulties in the activities of scientists in the early modern era?

The main difficulties of scientists of modern times was the complete lack of support from the church, which was guided in everything by religion and God’s scriptures.
In addition, for active scientific activity or contradictions expressed by scientists, they were subjected to terrible torture and even death at the sacred fire of the Inquisition.
Due to such cynicism on the part of the church and the complete lack of acceptance of scientifically grounded facts, the scientific progress of human development was almost completely stopped.