What caused the conflict between the North and the South of the United States?

In 1861, the first active measures for the struggle between north and south appeared. The cause of the American Civil War was mainly the uneven development of the economy. Intensive colonization prevailed in the North. In the South, plantation fields reigned. Disagreement reigned among the enemies about customs duties and taxes. The development of the entire continent was hindered by a slave society. Farmers and producers could not come to a common solution. The formation of the Republican Party did not find a response among the southerners.