What event can be considered the boundary separating the history of the Ancient World from the history of the Middle Ages?

One such event is the fall of the Western Roman Empire in 476 AD. The last Roman emperor, young Romulus Augustulus, was overthrown by the general Odoacer, who soon sent symbols of imperial power to the capital of the eastern Roman Empire. It should be noted that the fall of the Roman Empire did not happen in one year. In 410, Rome was captured by the Goths, and in 455 by the Vandals, and before that the Huns almost captured. This chronology is appropriate for Europe, for China or India, as well as for the civilizations of the Western Hemisphere, it is hardly suitable.