What is influenced by the proximity of continents to each other or their remoteness from each other?

First of all, the proximity of continents affects economic activity. People or even entire states have the opportunity to exchange food, experience and knowledge, at least before digital technologies began to actively develop. But the most important thing is that the proximity of the continents affects the flora and fauna, because many species migrated from the mainland to the mainland. But if the continents are far from each other, then the flora and fauna there are more unique, for example, in Australia.