What is the difference between the effect of anthropogenic factors from natural ones on living organisms

What is the difference between the effect of anthropogenic factors from natural ones on living organisms, ecosystems, and the biosphere?

1) Natural factors (biogenic and abiogenic) have always existed, long before the appearance of man, and the ecosystem can compensate for them over time. They can be either favorable or unfavorable, or neutral. They are more local, i.e. act, as a rule, in a relatively small space.

2) Anthropogenic factors have appeared relatively recently (with the advent of man), and most often they have an adverse effect with rare exceptions (creation of reserves, etc.), they are also more global (emissions of toxic substances into the atmosphere, the use of pesticides that are blown can spread over long distances). Nature cannot always compensate for their effect.