What is the probability of having a healthy child if a man with mild thalassemia anemia
What is the probability of having a healthy child if a man with mild thalassemia anemia (autosomal dominant inheritance) marries a healthy woman?
Let us designate the gene that causes the development of thalassemia in humans as C, then the gene that causes the absence of this disease will be designated as c.
As you know, homozygotes for the CC thalassemia gene die at an early age from severe thalassemia.
Cc heterozygotes have mild thalassemia and are therefore viable.
Male with mild thalassemia – Cc. It produces two types of sperm, c and C.
A healthy woman is homozygous for the recessive health gene – cc. It produces oocytes of the same type c.
The probable offspring of this married couple will be represented by the following options:
children with mild thalassemia (Cs) – 50%;
healthy children without thalassemia (сс) – 50%.
Answer: 50%.