What was the main reason for the aggravation of the Anglo-Russian contradictions?

1. England had economic interests in the Balkans and the Black Sea, therefore it was interested in trade relations with the Ottoman Empire. Russia, on the other hand, was striving for the Black Sea, which could nullify the monopoly of British trade in this region. England also sought to establish itself in the Caucasus, where it also faced Russia.
2. Russia was actively moving into Central Asia, which could not but disturb England, which had interests in this region, as well as in India.
3. Clash in Afghanistan.
4. Russia is active in the Far East.