Will pepsin work if the hydrochloric acid of gastric juice is neutralized with alkali?

The proteolytic enzyme pepsin is produced by the stomach glands in an unactivated form. Pepsinogen is converted to pepsin in an acidic environment. After transportation to the duodenum, where the reaction of the medium is alkaline, pepsin is deactivated. Therefore, if hydrochloric acid is deactivated with alkali, the reaction will change and pepsin will not work.

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